EACR Travel Fellowship Awards
نویسنده
چکیده
Rabs are initially synthesized as soluble proteins; for membrane attachment they require a posttranslational C20-prenylation. Rab GTPases are localized to the cytosolic face of the limiting membrane of organelles, where they function as regulators of distinct steps in membrane trafficking pathways. Rabs cycle between a GTP-bound active and a GDPbound inactive form, assisted by GEFs (guanine nucleotide-exchange factors) and GAPs (GTPaseactivating proteins) respectively. GTP-bound Rabs recruit specific effector proteins through which they regulate vesicle formation, actin-and tubulin-dependent vesicle movement and membrane fusion and fission.
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EACR Travel Fellowship Awards
GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) is a novel organoarsenical compound presently completing phase I trials in cancer patients who are refractory to treatment. GSAO targets the mitochondria of proliferating endothelial cells by binding to calcium-replete adenine nucleotide translocase on the inner mitochondrial membrane. Consequently, small solutes equilibrate across th...
متن کاملEACR Travel Fellowship Awards
A key characteristic of malignant cancers is the ability to overcome microenvironmental controls by host, invade tissue, and reach distant sites of the body to form metastases. Cancer cells can induce profound changes in the neighbouring tissue, which in turn provides an environment that favours local tumour growth, metastatic spreading, and contributes to drug response. The host microenvironme...
متن کاملEACR Travel Fellowship Awards
Prostate cancer as well as other solid cancers are embedded in and supported by the surrounding tumour microenvironment, which usually consists of fibroblasts, smooth muscle cells, endothelial cells and immune cells. In the prostate, fibroblasts and smooth muscle cells represent the bulk of the stroma in both normal and malignant conditions. In carcinomas, there are also pro-tumourigenic cancer...
متن کاملKansas state university.
1) Opening remarks Carol Shanklin announced the acceptance of nominations for the Saracheck Honors Fellowship The fellowship provides an award of up to $15,000 to a resident graduate student enrolled in a Ph.D. program at Kansas State University. Student’s research must be in a field of study relying significantly on contemporary molecular biological techniques. In addition to the Honors Fellow...
متن کاملEACR-20: The European Translational Oncology Meeting
The 20 biannual Meeting of the European Association of Cancer Research EACR-20 was held in Lyon, in July 2008. The Meeting successfully gathered researchers from basic, translational and clinical cancer research to exchange and discuss recent results in the areas of major interest. This review presents a meeting report and intends to be a portrait of the excellent research presented at EACR-20....
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